Organic Chemistry 4.1

The module will contain sections on carbon - carbon bond formation using acids and bases, rearrangements, nucleophilic aromatic substitutions, molecular orbital theory, and the strengths of acids and bases.

Methods and reactions used in modern organic chemistry including drug synthesis and natural product synthesis, asymmetric synthesis, heterocycles, Organometallic chemistry as applied to organic synthesis, radical reactions. Retrosynthetic analysis.

Comparison of reactions and the application of green chemistry principles.

1. Describe the mechanism for reactions such as carbon bond formations, common rearrangements and nucleophilic aromatic substitutions.

2. Use Molecular Orbital Theory to explain electrocyclic and cycloaddition reactions

3. Explain the acidity and basicity of organic compounds and interpret Hammett Equation results

4. Describe major reactions and reagents used in modern organic synthesis including drug synthesis and natural product synthesis

5. Explain the logic of the reactions and the reagents used in modern organic synthesis including the approach used to devise synthetic routes to organic compounds

6. Evaluate the synthetic pathways and their component reactions to determine suitability using a range of criteria including sustainability

7. Carry out a range of synthetic and analytical techniques within a laboratory setting appropriate to synthetic organic chemistry