Molecular Biology 2.2


This module describes the major advances in 21st century molecular biology approaches to the fields of clinical diagnostics, nucleic acid therapies, and online fundamental bioinformatic resources applying to these disciplines.  General gene cloning approaches in the initial has of biopharmaceutical production are also described.  A suite of appropriate wet and dry laboratory techniques will be included.

Learning Outcomes

  1. Describe the genomic features that underlie clinical conditions and serve as targets for biopharmaceutical development and interventions.

  2. Describe the epigenome, its role in phenotype expression, and the external factors that can detrimentally alter it during one’s lifespan and through future generations.

  3. Appreciate the ever-increasing influence of Next Generation Sequencing (NGS) methodologies in medical diagnostics and the subsequent development of precision clinical therapies.

  4. Appreciate the importance of modern gene manipulation tools, with emphasis on CRISPR.

  5. Use appropriate bioinformatics tools and web sites to examine and understand clinical conditions in detail.

  6. Use a variety of molecular biology laboratory instruments and associated protocols that are in general use in routine and clinical laboratories.

% Coursework 60%
% Final Exam 40%