This module reviews the pharmacokinetics and pharmacodynamics of chemical drug molecules. It describes the pharmacokinetics and pharmacodynamics of biotherapeutics with a particular emphasis on therapeutic antibodies.
Various therapeutic targets are evaluated (i.e. receptors, enzymes, ion channels & transporters), with particular emphasis on receptors and the signalling mechanisms initiated following receptor activation.
The module analyses the short-term regulation of cell function and the mechanisms involved in excitation, contraction, and secretion.
It also addresses the processes of cell replication, proliferation, apoptosis, repair, and regeneration and how they relate to the actions of drug therapies.
Critically evaluate the absorption, distribution, metabolism & elimination of chemical drug molecules
Evaluate targets for drug action, compare and contrast the structure and activation of different types of receptors as drug targets and evaluate signalling mechanisms that result in physiological effects
Analyse the mechanisms involved in the short-term regulation of cell function
Examine the stimulation and proliferation of cells and the pathways involved in programmed cell death, explain how these processes relate to tissue repair, and assess opportunities for intervention with novel therapies.
Critically evaluate the pharmacokinetics and pharmacodynamics of therapeutic proteins
Apply, process, and condense module material in the preparation of reports, posters, presentations, and in the completion of continuous assessment quizzes.